The study of the optical activity of some S-derivatives 4-R-5-((((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1, 2,4-triazole-3-thiols

About half of the drugs currently produced are chiral compounds, and about 90 % these compounds sold as racemates, consisting an equimolar mixture two enantiomers. Although they have same chemical structure, most optical isomers substances show marked differences in biological activity. It is known that presence a single asymmetric atom has become almost integral part advanced drug design. The aim this work was to determine angle rotation polarization plane solutions some S-derivatives 4-R-5-((((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl))-4H-1,2,4-triazole-3-thiols establishment regularities between structure studied molecules their Materials methods. subject study 2-[5-R1-4R2-1,2,4-triazole-3-ylthio]-1-aryletanols. newly synthesized carried out using Atago AP-300 polarimeter DFU 2.2.7 physical-chemical analysis method “Optical rotation”. Results. results were exhibit compound 1-((4-methyl-5-(((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-yl)thio)-2-phenylethan-1-ol (+43° [deg∙g/cm3∙dm]). only levorotatory substance 1-(4-fluorophenyl)-2-((4-methyl-5-(((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio))methyl)-4H-1,2,4-triazole-3-yl)thio)ethan-1-ol with specific [α]D20 = -43° [deg∙g/cm3∙dm]. Conclusions. Studies had shown 1-(4-fluorophenyl)-2-((4-methyl-5-(((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl))thio)methyl)-4H-1,2,4-triazole-3-yl)thio)ethan-1-ol able rotate light left, which evidence advantage S-enantiomer racemic mixture, therefore considerable interest for further preclinical research. Also, all other analyzed behave isomers.